Abstract
As part of a search for novel biologically active compounds in the Macrophage Scavenger Receptor (MSR) assay, the EtOAc extract of a gorgonian coral, Pseudopterogorgia rigida, was shown to be active. Bioassay-guided fractionation of the extract yielded curcuphenol, curcuhydroquinone, curcuquinone, and a novel o-quinone, rigidone (1). The structure and stereochemistry of 1 was determined by interpretation of spectral data and chemical transformation.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Cell Adhesion Molecules / drug effects
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Cell Adhesion Molecules / metabolism*
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Cell Line
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Cnidaria / chemistry*
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Humans
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Kidney / drug effects
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Kidney / metabolism
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Magnetic Resonance Spectroscopy
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Quinones / isolation & purification*
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Quinones / pharmacology
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Receptors, Immunologic / drug effects
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Receptors, Immunologic / metabolism*
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Receptors, Scavenger
Substances
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Cell Adhesion Molecules
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Quinones
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Receptors, Immunologic
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Receptors, Scavenger
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rigidone